摘要
利用哑铃型三嵌段聚己内酯(PCL)-聚乙二醇(PEG)-聚己内酯作为壁材,十二烷基硫酸钠为乳化剂,二氯甲烷为有机溶剂,去离子水为水相介质,通过W/O/W型复乳法制备替莫唑胺(Temozolomide,TMZ)载药微球。制得的载药微球粒径分布窄、平均粒径为2.20～2.42μm,载药量可达到9.01%,体外释放实验的缓释时间达到27 d以上。
Dendronized polycaprolactone-poly（ ethylene glycol）-polycaprolactone temozolomide-loaded microspheres were prepared by water/oil/water （W/O/W） double emulsion method with sodium dodecyl sulfate as emulsifier,dichloromethane as organic solvent, deionezed water as water medium. Microspheres with a range of 2.20 to 3.26 μm in mean diameter with narrow microsphere size distribution were achieved,drug loading could reach 9.01% and release time over 27 d.
出处
《塑料》
CAS
CSCD
北大核心
2012年第6期75-77,56,共4页
Plastics
关键词
复乳法
缓释微球
树枝化聚合物
聚己内酯
替莫唑胺
double emulsion method
sustained-release microsphere
dendronized polymer
polycaprolactone
temozolomide
