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急性心肌梗死急诊经皮冠状动脉介入术后N末端脑利钠肽前体浓度与左室重构、心功能变化的研究 被引量:13

Changes in plasma NT-proBNP and left ventricular remodeling and heart function in patients with acute myocardial infarction after PCI
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摘要 目的探讨急性心肌梗死急诊经皮冠状动脉介入术(PCI)前后血浆N末端脑利钠肽前体(NT-proBNP)浓度与左室形态和心功能的变化。方法急性心肌梗死患者51例分为急诊PCI术组29例和常规药物组22例,于急诊介入术前或入院24 h内及入院第7天检测血浆NT-proBNP,入院24 h时内及心梗1个月后行超声心动图检测左室舒张末期内径,左室舒张末期容积,左心室射血分数,分析NT-proBNP的变化与左室重构的关系。结果两组的NT-proBNP在治疗前后均明显下降,左心室射血分数增高;直接PCI组较药物治疗组治疗后血浆NT-proBNP明显下降。结论急性心肌梗死患者中NT-proBNP能够有效反应心功能的变化,早期的PCI治疗可以改善左室的收缩功能,明显降低血浆NT-proBNP的水平。
出处 《中国生化药物杂志》 CAS CSCD 北大核心 2012年第6期863-865,共3页 Chinese Journal of Biochemical Pharmaceutics
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