吸入麻醉对T细胞亚群和NK细胞的影响

Effects of Inhalation Anesthetic on T-Lymphocyte Subsets and Natural Killer Cell Activity

目的 :观察异氟醚和安氟醚吸入麻醉对病人T细胞亚群、自然杀伤细胞 (NK细胞 )的影响。方法 :38例行肺叶切除术的病人 ,随机分为异氟醚麻醉组 2 0例、安氟醚麻醉组 18例。术前、麻醉后 1小时、术后 1天、术后 1周、术后 2周分别检测血清T细胞亚群及NK细胞活性。结果 :异氟醚组和安氟醚组术后的NK细胞活性均降低 ,异氟醚组T细胞亚群无明显改变 ,安氟醚组的CD4 活性降低 ,CD8活性升高 ,CD4 /CD8比值下降。结论

Objective:To investigate the effects of inhalation anesthetic on T lymphocyte subsets and natural killer(NK) cell activity.Methods:Thirty eight patients undergoing pneumonectomy were randomly allocated into isoflurane anesthesia group ( n= 20) and enflurane anesthesia group ( n= 18).The blood samples were obtained before anesthesia,at one hour after anesthesia,on one day,one week,two weeks after operation.The plasma levels of T lymphocyte subsets and NK cell activity were measured.Results:The activity of NK cell was lower than the baseline in two groups.The levels of CD 8 were higher than the baseline.CD 4 and CD 4/CD 8 ratio were lower than the baseline in enflurane group.No significant differences were found in the levels of CD 4,CD 8 and the ratio of CD 4/CD 8 in isoflurane group.Conclusion:The suppression effect of cell mediated immunity in enflurane group is more significant than that in isoflurane group.