全氟碳纳米粒载体靶向诊断治疗的研究

Research on Perfluorocarbon Nanoparticles Carrier in the Targeted Diagnosis and Treatment

全氟碳纳米粒是近年来出现的一种新型药物载体,它具有很多独特的性能,如化学稳定性好、生物相容性好、携氧能力高、靶向性组织细胞作用等。现综述全氟碳纳米粒的理化性质和应用研究,总结其作为一种靶向载体在心血管系统、神经系统疾病及肿瘤的诊断和治疗方面的研究进展,进一步阐述其可以选择性作用于靶细胞、组织,快速释放药物,从而达到满意的治疗效果,并认为全氟碳纳米粒作为载体靶向诊断治疗具有较好的前景和临床应用价值。

The perfluorocarbon （PFC） nanoparticle is a sort of new drug carrier in recent years, and it has lots of u nique properties such as chemical stability, favourable biocompatibility, high aerobic capacity, targeting action to tis sues or cells and so on. In this paper, we summarize the physieochemical properties of the PFC nanopartieles. We also show the research progress of the PFC nanoparticles as a kind of drug carrier for targeted therapy of cardiovascu lar system, nervous system diseases and tumor. Further more, its characteristics of being selectively in target cells, tissues, and rapid release of drugs are expounded. PFC nanoparticles, as drug carriers for targeted diagnosis and treatment, have good prospect and clinical application value.