江浙沪地区HLA-DQB1基因对重症肌无力的遗传易感性研究

Study on HLA-DQB1 polymorphism to myasthenia gravis susceptibility in Chinese Jiangzhehu areas

目的 :探讨中国汉人MG易感性与HLA DQB1基因多态性的相关性。方法 :运用PCR RFLP法进行HLA DQB1基因分型。结果 :MG病例组 (包括亚组 )与对照组比较都有DQB1 0 30 3频率的明显增高 ,DQB1 0 6 0 1和DQB1 0 6 0 2频率的明显降低 ,差异都有显著性。结论 :DQB1 0 30 3参与中国汉人MG的易感性 ,而DQB1 0 6 0 1和DQB1 0 6 0

Objective:Analyze the association HLADQB1 gene polymorphism and MG susceptibility in Chinese Hans. Methods:HLADQB1 were genetyped using PCRRFLP. Results:Compared the frequency of HLADQB1 alleles between MG patients (included subgroups) and the healthy controls. The frequency of DQB1*0303 was significantly increased,and the frequency of DQB1*0601 and DQB1*0602 was significantly decreased. The differences were statisticaly. Conclusion:DQB1*0303 was susceptible to MG in Chinese Hans. DQB1*0601and DQB1*0602 were protective genes.