病毒性肝炎患者血清γ-IFN与肝纤维化关系的研究

Study on the correlation between serum gama-IFN and liver fibrosis in viral hepatitis

目的 :研究病毒性肝炎患者γ IFN与肝纤维化指标HA、LN、PCⅢ血清水平的变化 ,探讨其在肝纤维化机制中的作用。方法 :对 80例各种类型病毒性肝炎检测血清γ IFN、HA、LN、PCⅢ ,并与肝组织病理学变化进行对照研究。结果 :γ IFN在AH、CH、LC组中依次降低 ,γ IFN与HA、PCⅢ血清水平负相关 ,并且γ IFN血清水平降低与肝脏病理学纤维组织增生程度有关。结论 :γ IFN是病毒性肝炎发病及肝纤维化进展过程中重要的细胞因子 。

Objective:The aim of article is to study serum gamaIFN ,HA, LN and PCⅢ change in patients with viral hepatitis and discuss their function in the mechanism of liver fibrosis.Methods:Serum gamaIFN, HA, LN and PCⅢ were examined in 80 patients with viral hepatitis and contrast study were performed between those serum markers and hepatic pathology.Results:The level of serum gamaIFN decreased successively in group AH, CH, LC. In addition, the serum gamaIFN level and HA, PCⅢ were negative correlation. Besides the decrease of serum gamaIFN level and liver fibrosis were correlation.Conclusion:Serum gamaIFN is an important cytokine in occurrence of viral hepatitis and in the development of liver fibrosis in viral hepatitis.