经皮椎体成形术联合唑来膦酸治疗脊椎骨转移癌疼痛

Treatment of Spinal Vertebra Metastases Pain with Combination of Prcutaneous Vertebroplasty and Zoledronic Acid

目的观察经皮椎体成形术联合双膦酸盐治疗脊椎骨转移癌的疗效及不良反应。方法将46例脊椎骨转移癌患者分为治疗组和对照组,治疗组21例行经皮椎体成形术治疗,同时静脉滴注唑来膦酸4mg每4周1次,连续2次后评价疗效和不良反应;对照组25例给予常规止痛药物治疗。结果治疗组脊椎骨转移癌患者的骨痛完全缓解8例,部分缓解9例,有效率为81.0%,生活质量改善有效率为95.2%,与对照组相比差异有统计学意义(P<0.05);治疗组主要不良反应有发热、恶心、呕吐等。结论经皮椎体成形术联合双膦酸盐治疗脊椎骨转移癌的止痛疗效迅速,可防止骨转移癌的进展,提高生活质量,其不良反应患者可以耐受。

Objective To evaluate the efficacy and side events of the treatment of spinal vertebra metastases with combination of percutaneous vertebroplasty and bisphosphonates. Methods 46 patients suffered from spinal vertebra metastases were observed in the research.21 cases in surgeon group were given percutaneous vertebroplasty, and meanwhile intravenous infusion of Zoledronic Acid was given as 4mg every 4 weeks. We evaluate the efficacy and side events of the treatment after percutaneous vertebroplasty and 2 cycles of Zoledronic Acid.On the other hand, 25 cases in control group were given normal anti-pain treatment. Results Out of the 21 patients in surgeon group, 8 cases achieved complete remission and 9 cases achieved partial remission.Bone pain relief provided by the treatment was 81.0% and the efficacy in increasing quality of life was 95.2%.There were both significant statistical differences between two groups （P〈0.05）.The side events observed was fever, nausea and vomiting.Conclusion The treatment with combination ofpercutaneous vertebroplasty and bisphosphonates can quickly release bone pain and increase quality of life of the patients.It is safe and effective for spinal vertebra metastases and its side events are minor and tolerable.