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循环肿瘤细胞在乳腺癌中检测和应用的研究进展

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摘要 在我国,乳腺癌是导致妇女死亡的主要原因之一,其中远处转移的发生是导致乳腺癌患者死亡的最主要原因。然而,肿瘤细胞转移机制目前尚不清楚。当前,肿瘤检测手段严重依赖于影像学和血清标志物。基于肿瘤细胞播散理论,检测循环肿瘤细胞(CTC)有可能早期发现肿瘤转移和复发情况。因此,本文就相关的CTC成像、检测技术和近期发现的CTC特性分子加以概述。
出处 《中国老年学杂志》 CAS CSCD 北大核心 2012年第23期5347-5350,共4页 Chinese Journal of Gerontology
基金 吉林省卫生厅科研课题(No.2010Z086) 吉林省自然科学基金项目(201215215)
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  • 1Ashworth TR. A case of cancer in which cells similar to those in the turnouts were seen in the blood after death [ J ]. Med J Australia, 1869; 14 : 146-7.
  • 2Cristofanilli M, Budd GT, Ellis MJ, et al. Circulating tumor cells, disease progression, and survival in metastatic breast cancer[ J ]. N Engl J Med, 2004 ;351:781-91.
  • 3Tibbe AG, Miller MC, Terstappen LW. Statistical considerations for enu- meration of circulating tumor eells[ J]. Cytometry A ,2007 ;71 : 154-62.
  • 4Fehm T, Solomayer EF, Meng S, et al. Methods for isolating circulating epithelial cells and criteria for their classifieation as eareinoma ceils [J]. Cytotherapy ,2005 ;7 : 171-85.
  • 5K3nigsberg R, Obermayr E, Bises G, et al. Detection of EpCAM positive and negative circulating tumor cells in metastatic breast caneer patients [ J]. Acta Oneol,2011 ;50:700-10.
  • 6Sieuwerts AM, Kraan J, Bolt J, et al. Anti-epithelial cell adhesion mole- cule antibodies and the detection of circulating normal-like breast tumor cell[J]. J Natl Cancer Inst ,2009 ; 101:61-6.
  • 7Mostert B, Kraan J, Bolt-de Vries J, et al. Detection of circulating tumor cells in breast eancer may improve through enrichment with anti-CD146 [J]. Breast Cancer Res Treat,2011 ;127:33-41.
  • 8Sehindlbeek C, Stellwagen J, Jeschke U, et al. Immunomagnetic enrich- ment of disseminated tumor cells in bone marrow and blood of breast cancer patients by the Thomsen-Friedenreich-Antigen [ J ]. Clin Exp Me- tastasis, 2008 ; 25 : 233 -40.
  • 9Deng G, Herder M, Burgess D, et al. Enrichment with anti-cytokeratin a-lone or combined with anti-EpCAM antibodies significantly increases the sensitivity for circulating tumor cell detection in metastatic breast cancer patients [J].Breast Cancer Res,2008 ; 10 (4) : R69.
  • 10Vona G, Sabile A, Louha M, et al. Isolation by size of epithelial tumor cells:a new method for the immunomorphological and molecular charac- terization of circulating tumor cells[ J]. Am J Patho1,2000 ; 156:57-63.

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