摘要
采用胶原酶建立大鼠脑出血模型 ,进行神经症状记分和脑组织内亚硝酸盐诱导型一氧化氮合酶 (iNOS)检测。结果表明脑溢安颗粒剂治疗组大鼠神经缺损症状恢复快 ,脑组织内亚硝酸盐及iNOS呈低水平表达。提示脑溢安颗粒剂抑制大鼠实验性脑出血后脑内iNOS的过度表达可能是其药效机制之一。
In order to establish a model of intracerebral hemorrhage(ICH), 0.4 U bacterial collagenase was injected stereotaxically into globus pallidus in rats. Neurological deficit score was investigated, and inducible nitric oxide syntahse(iNOS) mRNA was detected in 72 rats. The results showed that: in the group treated by naoyian granule(NYA), the recovery time was shorter than that in other groups, and low concentration nitrite and weak signal of iNOS mRNA were found. It suggests that inhibition of iNOS induction is one of the pharmacological effects of NYA. [
出处
《湖南医科大学学报》
CSCD
2000年第3期245-247,共3页
Bulletin of Hunan Medical University
基金
国家自然科学基金资助项目!(39670907)
关键词
脑出血
脑溢安颗粒剂
一氧化氮
大鼠
中医药疗法
intracerebral hemorrhage
nao-yi-an granule
nitric oxide
rats
drug utilization
