相近分化的肺鳞癌和腺癌中PCNA及EGFR表达的研究

Study on the expression of EGFR and PCNA in lung squamous cell carcinomas and lung adenocarcinomas of near differentiation

目的 :探讨 PCNA和 EGFR在肺鳞癌、腺癌中的表达及与癌组织分型、淋巴结转移等方面的关系。方法 :用免疫组化 S- P法分别对 44例分化相近肺癌组织、1 6例正常肺组织 PCNA和EGFR的表达进行检测。结果 :肺癌组织 PCNA和 EGFR的表达明显高于正常肺组织。鳞癌与腺癌比较 ,PCNA和 EGFR表达无统计学差别 ( P>0 .0 5)。淋巴结转移阳性癌组织 PCNA和 EGFR表达与淋巴结转移阴性癌组织比较 ,无统计学差别 ( P>0 .0 5)。结论 :PCNA和 EGFR参与了肺癌的发生发展 ,在肺癌中表达有一定相关性。二者与鳞癌、腺癌分型无关 ,与淋巴结转移与否无关。

Objective:To study the expression of EGFR,PCNA in squamous cell lung carcinoma and lung adenocarcinomas and to investigate the relationship between their overexpression and lung cancer typing,lymphaden metastases.Methods:Immunohistochemistry was used to detect the expression of EGFR,PCNA in 44 cases of lung carcinomas of near differentiation,16 cases of normal lung tissues.Results:The expression of EGFR and PCNA in lung cancer was significantly higher than that in normal lung tissues.Compared to that of squamous carcinomas,the positive expression of EGFR and PCNA in adenocarcinomas wasn′t significantly different.The carcinoma tissues with EGFR overexpression also had a tend of PCNA overexpression.The expression of EGFR,PCNA wasn′t significantly different between cancer tissues with lymphaden metastases and those without lymphaden metastases.Conclusion:The result suggests:The overexpression of EGFR,PCNA is related to the occurrence and development of lung cancer, and it has nothing to do with lung cancer typing.No significant correlations were found between EGFR,PCNA overexpression and lymphaden metastases.The expression of EGFR is related to that of PCNA and their detection is useful in prognosis. 〔