氧自由基在小儿急性病毒性脑炎血清中检测的临床意义

Clinical significance of serum oxygen free radicals in detection of children with acute virus encephalitis

目的 :探讨氧自由基在小儿急性病毒性脑炎发病机理中的作用。方法 :采用化学方法分别检测 48例小儿病脑急性期和恢复期血清中超氧化物歧化酶 ( SOD) ,谷胱甘肽过氧化物酶( GSH- Px) ,过氧化氢酶 ( CAT)的活性变化和脂质过氧化物 ( ( LPO)含量变化。结果 :急性期 SOD,GSH- Px和 CAT的活性明显低于恢复期和正常对照组 ;急性期 LPO的含量明显高于恢复期和正常对照组。结论 :在小儿病脑发病过程中存在着自由基代谢紊乱 ,自由基参与了病脑的病理过程。这一检测结果为临床应用自由基清除剂、估计病情及预后提供了可靠的理论依据。

Objective:To study the pathological role of oxigen free radicals in chidren with acute virus encephalitis.Methods:The activity of superoxide dismutase (SOD),glucathione perioxide (GSH Px) and catalase (CAT) and the content of lipid peroxidase (LPO) in serum at acute stage and recovery stage were detected respectively by chemical technique in 48 children with acute virus encephalitis.Results:The activity of SOD,GSH Px and CAT was much lower at acute stage than that at recovery stage and in normal persons;while the content of LPO at acute stage was higher than that at recovery stage and in normal persons.Conclusion:There was metabolic disorder of oxigen radicals in patients with acute encephalitis and the oxigen radicals played an important role in the pathological course of acute virus encephalitis in children.It was very important to detect the above enzymes for the prognosis,evaluation and treatment of acute virus encephalitis. 〔