期刊文献+

二甲双胍在大鼠酒精性肝损伤中的保护作用及其机制 被引量:2

Protective effect and mechanism of metformin in rats with alcoholic liver disease
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摘要 酒精性肝病(ALD)的发病与脂质代谢紊乱、肝细胞线粒体内脂肪酸氧化障碍和氧化应激等有关.腺苷酸活化蛋白激酶(AMPK)被称为细胞的“代谢感受器”,存在于线粒体内,其信号通路是调节细胞能量状态的中心环节,AMPK激活后可以提高胰岛素敏感性、增加脂肪酸氧化及改善氧化应激。
出处 《中华肝脏病杂志》 CAS CSCD 北大核心 2012年第12期948-950,共3页 Chinese Journal of Hepatology
基金 基金项目:河北省医学重点课题(20090141)
关键词 肝疾病 酒精性 大鼠 二甲双胍 预防和防护用药 胰岛素抗药性 Liver disease, alcoholic Rats Metformin Protectiver agents Insulin resistance
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参考文献8

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二级参考文献10

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共引文献5

同被引文献20

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