微小RNA在胰腺导管腺癌诊断、治疗和预后评估中的研究进展

Research progress of microRNA in diagnosis,treatment and prognosis evaluation for pancreatic ductal adenocarcinoma

微小RNA(miRNA)是一类非编码短链RNA,长度为17～25个核苷酸,在转录后水平调控基因表达。近年来研究发现miRNA在多个肿瘤的发生、发展、侵袭及转移等方面起作用。胰腺导管腺癌(PDAC)是预后极差的恶性肿瘤,至今仍缺乏可靠的早期诊断标志物和有效的治疗方法。文章重点介绍异常的miRNA表达谱在PDAC诊断、治疗和预后评估中的相关研究进展。

MicroRNA （miRNA） are a class of short noneoding RNAs, with 17 -25 nucleotides in length, which play a role in the regulation of gene expression at post-transcriptional level. Recent studies have revealed that miRNA may be associated with pathogenesis, progression, invasion and metastasis of tumors. Pancreatic ductal adenocarcinoma （PDAC） is a lethal cancer which is characterized by the absence of biomarkers for early diagnosis and effective strategies for therapeutic intervention. The current status of miRNA in diagnosis, treatment and prognosis evaluation for PDAC is introduced in this paper.