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TrkB信号转导通路在肿瘤中的作用 被引量：4

Role of TrkB signal transduction pathway in tumors
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摘要 神经营养因子-酪氨酸激酶受体(NT-Trk)信号通路在神经细胞的发育、生长中发挥重要的调控作用。近年来发现Trk还参与了许多恶性肿瘤的发病机制。研究认为TrkB表达与肿瘤生成有关,脑源性生长因子(BDNF)/TrkB信号转导通路激活赋予肿瘤存活、血管生成、化疗耐药和失巢凋亡抑制能力。该文就TrkB信号转导通路在肿瘤中的作用作一综述。 Neurotrophin-tyrosine kinase receptor （NT-Trk） signaling pathway plays an important role in the neural regulation of development. Now it has been recently revealed that Trk may also participate in the pathogenesis of many malignant tumors. It is demonstrated that the expression of TrkB is related to oncogenesis. The activation of brain-derived neurotrophic factor （BDNF）/TrkB signal transduction pathway stimulates tumor cell survival and angiogenesis, and contributes to the resistance to cytotoxic drugs and anoikis. The role of TrkB signal transduction pathway in tumors is reviewed in this paper.
作者 鲍伟 于晓辉 万小平
机构地区 上海交通大学医学院附属国际和平妇幼保健院妇科 大连市妇产医院妇科
出处 《上海交通大学学报（医学版）》 CAS CSCD 北大核心 2012年第12期1652-1655,共4页 Journal of Shanghai Jiao tong University:Medical Science
关键词 神经营养因子 酪氨酸激酶受体 脑源性神经营养因子 失巢凋亡抑制 Trk抑制剂 neurotrophin tyrosine kinase receptor brain-derived neurotrophic factor anoikis resistance Trk inhibitors
分类号 R730.2 [医药卫生—肿瘤]
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参考文献24

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同被引文献30

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  • 7梅旭晖,纪倩,姚斌彬,等.推拿对坐骨神经损伤大鼠p75NTR的影响[DB/OL].中国科技论文在线2013[2013-10-12].ht-tp://www.paper.edu.on/releasepaper/content/201303-298.
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  • 10SeshiB, Kumar S, King D. Multilineage gene expression in hu- man bone marrow stromal cells as evidenced by single - cell mi- croarray analysis[J] Blood Cells Mol Dis, 2003, 31(2) : 268 - 285.

引证文献4

二级引证文献14

上海交通大学学报（医学版）
2012年 第12期

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