摘要
组织蛋白酶L(cathepsin L,CTSL)是溶酶体半胱氨酸蛋白酶家族的主要成员,具有非常独特的合成和转运方式.CTSL前体酶原的前体肽含有ERF/WNIN模体和GNFD模体.CTSL的空间结构主要由α螺旋构成的L结构域以及由β折叠构成的R结构域组成.大量研究工作表明,CTSL在体内生理和病理过程中,以及在寄生动物中都发挥着极其重要的功能.其生理作用广泛涉及到蛋白质水解、抗原提呈、T细胞分选、细胞凋亡以及胚胎发育等方面.CTSL还与多种类型的肿瘤发生、心血管疾病以及肾病等密切相关.另外,CTSL在寄生动物中也发挥着独特的作用.本文针对CTST的最新研究进展做了简要总结及分析,并指出了相关研究的发展趋势.
Cathepsin L (CTSL) is a member of the lysosomal cysteine protease superfamily with an unique manner of synthesis and transportation. The precursor peptide of CTSL preproenzyme contains the ERF/WNIN motif and GNFD motif in the primary structure, and contains an L domain of a-helix and an R domain of β-sheet in the spatial structure. CTSL plays extremely important roles in physiological and pathological processes in human and parasitic animals. Its physiological roles are widely involved in proteolysis, antigen-presenting, T cell development, cell apoptosis, and embryonic development, etc. It is also related to the development of cancer, cardiovascular diseases and kidney diseases. In addition, CTSL plays a special role in parasitic animals. Here, we focused on the recent advances regarding this study.
出处
《中国生物化学与分子生物学报》
CAS
CSCD
北大核心
2012年第12期1093-1099,共7页
Chinese Journal of Biochemistry and Molecular Biology
基金
教育部新教师基金(No.20112136120002)
大连市科学技术基金(No.2011J21DW014)
辽宁省教育厅科学研究一般项目(No.L2011187)资助~~
关键词
组织蛋白酶L
前体酶原
生理作用
病理活动
寄生动物
cathepsin L (CTSL)
preproenzyme
physiological role
pathological activity
parasitic animal