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microRNA在心脏发育和心脏疾病中的作用 被引量：4

The Function of MicroRNAs in Heart Development and Disease
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摘要 microRNA是一种内源性的小核苷酸片段,它可以通过促进mRNA的降解或抑制mRNA的翻译对其靶基因的表达发挥负调控作用.最近的研究报道,一系列心脏特异性的microRNA能够调控心脏的发育过程,包括心肌细胞分化、增殖、凋亡和衰老等.另外,microRNA在一些心脏疾病的发生、发展中发挥作用,包括心肌肥大、心律失常、心肌梗死、心力衰竭等.本文综合近期的研究,对microRNA在心脏发育和心脏疾病中的作用进行综述. are endogenous small non-protein-coding RNAs which act as negative regulators of their target gene expression by promoting mRNA degradation or inhibiting mRNA translation. Recently, a series of cardiac-specific microRNAs have been reported to control the heart development, including the differentiation, proliferation, apoptosis and senescence of cardiomyocytes. In addition, microRNAs participate in many pathophysiological processes in the heart, including cardiac hypertrophy, arrhythmia, myocardial infarction, and heart failure. Here, we summarize recent studies to review microRNA roles in heart development and heart diseases.
作者 王家骥 贾竹青 周春燕
机构地区 北京大学医学部基础医学院生物化学与分子生物学系
出处 《中国科学：生命科学》 CSCD 北大核心 2012年第12期957-966,共10页 Scientia Sinica(Vitae)
基金 国家自然科学基金(批准号:90919022 81070112) 教育部及国家外国专家局高等学校学科创新引智计划(批准号:B07001)资助项目
关键词 MICRORNA 心脏发育 心脏疾病 microRNA, heart development, heart disease
分类号 R541 [医药卫生—心血管疾病]
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参考文献65

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同被引文献39

  • 1吴红霞,李永青,吴秀山.脊椎动物心脏形态发育的转录调控[J].生命科学研究,2002,6(S2):101-105. 被引量：56
  • 2付金容,唐其柱,沈涤非.整合素β_1在自身免疫性心肌炎小鼠心肌的表达[J].心脏杂志,2005,17(1):25-28. 被引量：7
  • 3Strauer BE, Steinhoff G. 10 years of intracoronary and in- tramyocardial bone marrow stem cell therapy of the heart: from the methodological origin to clinical practice [ J ]. J Am Coll Cardiol, 2011, 58 ( 11 ) : 1095-1104.
  • 4Vlassov AV, Magdaleno S, Setterquist R, et al. Exo- somes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials [ J ]. Biochim Biophys Acta, 2012, 1820(7):940-948.
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  • 6Wen Z, Zheng S, Zhou C, et al. Repair mechanisms of bone marrow mesenchymal stem cells in myocardial infarc- tion[J]. J Cell Mol Med, 2011, 15(5) :1032-1043.
  • 7Wen Z, Zheng S, Zhou C, et al. Bone marrow mesenchy- mal stem cells for post-myocardial infarction cardiac re- pair: microRNAs as novel regulators[ J]. J Cell Mol Med, 2012, 16(4) :657-671.
  • 8Tijsen AJ, Pinto YM, Creemers EE. Circulating microR- NAs as diagnostic biomarkers for cardiovascular diseases [J]. Am J Physiol Heart Cire Physiol, 2012, 303(9): H1085-H1095.
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  • 10Tang Y, Zheng J, Sun Y, et al. MicroRNA-1 regulates cardiomyocyte apoptosis by targeting Bel-2 [ J ]. Int Heart J, 2009, 50(3):377-387.

引证文献4

二级引证文献14

中国科学：生命科学
2012年 第12期

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