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亚低温对脑损伤大鼠海马区Cyt-C、Bcl-XL、Bcl-XS表达的影响 被引量：5

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摘要 研究表明细胞色素C（cytochrome C，Cyt-C）自线粒体释放人胞浆是诱导细胞凋亡的关键环节。Bcl-2基因家族是细胞凋亡过程中一类重要的调节因子，包含两类功能相反的基因：一类是抑制细胞凋亡的基因，如Bcl．2和Bcl-W等；另一类是促进细胞凋亡的基因，如Bax、Bak和Bcl-Xs等。
作者 宋宇 王立义 魏志玄
机构地区 南阳高等专科学校第一附属医院神经外科
出处 《中华急诊医学杂志》 CAS CSCD 北大核心 2012年第12期1319-1321,共3页 Chinese Journal of Emergency Medicine
关键词 BCL-XL BCL-XS CYT-C BCL-2基因家族 海马区 脑损伤 亚低温 诱导细胞凋亡
分类号 R651.15 [医药卫生—外科学]
  • 相关文献

参考文献14

  • 1Busto R, Dietrich WD, Globus MY, et al. Small difference in intraischemic brain temperature critically determine the extent of ischemic neuronal injury [Jl. Cereb Blood Flow Metab, 1987, 7 (6) : 729-738.
  • 2Jiang JY, Lyeth BG, Clifton GL, et al. Relationship between body and brain temperature in traumatically brain-injured rodents [ J ]. Neurosurgery, 1991, 74 (3) : 492-496.
  • 3花嵘,李春盛.亚低温用于心搏骤停后脑保护的研究进展[J].中华急诊医学杂志,2010,19(10):1109-1111. 被引量：15
  • 4Xu L, Yenari MA, Steinberg GK. Mild hypothermia reduces tpoptosis of mouseneurons in vitro early in the cascade [ J ] . Cereb Blood Flow Metab, 2002, 22 (1): 21-28.
  • 5张京晓,尹永杰.亚低温治疗的新进展[J].中华急诊医学杂志,2010,19(2):217-218. 被引量：11
  • 6Maier CM, Ahem KV, Cheng ML, et al. Optimal depth and duration of mild hypothermia in a focal model of transient cerebral ischemia: effects on neurologic outcome, infarct size, apoptosis, and inflammation [J]. Stroke, 1998, 29 (10) : 2171-2180.
  • 7Prakasa-Babu P, Yoshida Y, Su M, et al. Immunohistochemical expression of Bcl-2, Bax and cytochrome-c following focal cerebral ischemia and effect of hypothermia in rat [ J I. Neurosci Lett, 2000, 291 (3) : 196-200.
  • 8Phanithi PB, Yoshida Y, Santana A, et al. Mild hypothermia mitigates post-ischemic neuronal death following focal cerebral ischemia in rat brain : immunohistochemical study of Fas, caspase-3 and TUNEL [J]. Neuropathology, 2000, 20 (4) : 273-282.
  • 9王光伟,刘运生,丰昀,李创华.局灶亚低温对创伤性脑损伤后大鼠脑组织炎症反应的影响[J].中华急诊医学杂志,2008,17(12):1289-1291. 被引量：4
  • 10Yenari MA, Iwayama S, Cheng D, et al . Mild hypothermia attenuates cytoehrome e release but does not alter Bcl-2 expression or caspase activation after experimental stroke [ J ]. Cereb Blood Flow Metab, 2002, 22 (1): 29-38.

二级参考文献104

  • 1张银清,陈汉民,余锦刚,尹家和,黄国河.重型脑损伤亚低温治疗前后体液免疫功能的变化[J].临床军医杂志,2004,32(6):23-25. 被引量：3
  • 2李卫,姜晓丹,徐如祥.颅脑损伤后免疫状态的改变[J].中华神经医学杂志,2005,4(3):322-324. 被引量：8
  • 3王光伟,刘运生,梁有明,屈洪涛,李创华.局灶亚低温治疗创伤性脑损伤的最佳灌流温度[J].中华急诊医学杂志,2006,15(1):41-43. 被引量：6
  • 4黄子通,符岳.心搏骤停后脑缺血缺氧损害与脑复苏[J].中华急诊医学杂志,2006,15(1):93-94. 被引量：18
  • 5Biagas KV, Gaeta ML. Treatment of traumatic brain injury with hypothermia [J]. Curr Opin Pediatr, 1998,10(3):271-277.
  • 6Dearden NM. Mechanisms and prevention of secondary brain damage during intensive care [J]. Clin Neuropathol, 1998,17(4) :221-228.
  • 7Ueda Y, Wei EP, Kontos HA, et al. Effects of delayed, prolonged hypothermia on the pial vascular response after traumatic brain injury in rats [J].J Neurosurg, 2003,99(5):899-906.
  • 8Sakamoto KI, Fujisawa H, Koizmni H, et al. Effects of mild hypothermia on nitric oxide synthesis following contusion trauma in the rat [J]. J Neurotrauma, 1997,14(5) :349-353.
  • 9Chatzipanteli K, Wada K, Busto R, et al. Effects of moderate hypothermia on constitutive and inducible nitric oxide synthase activities after traumatic brain injury in the rat [J]. J Neurochem, 1999,72(5):2047- 2052.
  • 10Povlishock JT, Buki A, Koiziumi H, et al. Initiating mechanisms involved in the pathobiology of traumatically induced axonal injury and interventions targeted at blunting their progression [J]. Acta Neurochir Suppl (Wien), 1999,73:15-20.

共引文献51

同被引文献72

  • 1裘五四,刘伟国,沈宏,王卫民,章志量,张瑛,江素君,杨小锋.Therapeutic effect of mild hypothermia on severe traumatic head injury[J].Chinese Journal of Traumatology,2005,8(1):27-32. 被引量：22
  • 2陈华文,祝伟,李树生,郑智.重型颅脑损伤死亡危险因素的分析[J].中华急诊医学杂志,2006,15(3):216-218. 被引量：39
  • 3栗明,蒋更如.高低通量血液透析膜清除溶质能力的比较[J].中国组织工程研究与临床康复,2007,11(31):6207-6210. 被引量：16
  • 4He D,Zhao L,Li L,et al.Changes of blood flow perfusion by MR and NF-kappabeta expression in the region of perihematoma after experimental intracerebral hemorrhage:a correlation study[J] .Int J Neurosci,2009,119(6):806-814.
  • 5Ito H,Yamamoto N,Arima H,et al.Interleukin-1 beta induces the expression of aquaporin-4 through a nuclear factor-kappaB pathway in rat astrocytes[J] .J Neurochem,2006,99 (1):107-118.
  • 6Xue M,Del Bigio MR.Intracerebral injection of autologous whole blood in rats:time course of inflammation and cell death[J] .Neurosci Lett,2000,283(3):230-232.
  • 7Longa EZ,Weinstein PR,Carlson S,et al.Reversible middle cerebral artery occlusion without craniectomy in rats[J] .Stroke,1989,20(1):84-91.
  • 8Wang YX,Yan A,Ma ZH,et al.Nuclear factor-κB and apoptosis in patients with intracerebral hemorrhage[J] .J Clin Neurosci,2011,18(10):1392-1395.
  • 9Aronowski J,Hall CE.New horizons for primary intracerebral hemorrhage treatment:experience from preclinical studies[J] .Neurol Res,2005,27 (3):268-279.
  • 10Akizuki M,Yamashita H,Uemura K,et al.Optineurin suppression causes neuronal cell death via NF-κB pathway[J] .J Neurochem,2013,126(6):699-704.

引证文献5

二级引证文献23

中华急诊医学杂志
2012年 第12期

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