摘要
目的:研究Livin和Caspase-3在喉鳞癌组织中的表达及其相关性。方法:免疫组化SP法检测Livin和Caspase-3蛋白在30例声带息肉和62例喉鳞癌组织中的表达情况。结果:Livin在喉鳞癌组织中的表达高于声带息肉组织,Caspase-3的表达低于声带息肉组织(P<0.05);Livin和Caspase-3的表达在淋巴结有无转移、不同临床分期及不同分化程度之间的差异有统计学意义(P<0.05),在不同临床分型、有无吸烟史、不同年龄及性别方面的差异无统计学意义(P>0.05)。Livin与Caspase-3在喉癌组织中表达呈负相关(rs=-0.448,P<0.05)。结论:Livin和Caspase-3关系密切,两者异常表达可能在喉鳞癌的发生发展及转移中发挥重要作用。
Objective： To investigate the expression and correlation analysis of Livin and Caspase-3 in laryngeal squamous cell carcinoma. Methods： Immunohistochemistry was used to detect the expression of Livin and Caspase-3 in 30 cases of vocal cord polyp and 62 cases of laryngeal squamous cell carcinoma. Results： The expression of Livin was Significantly higher in laryngeal squamous cell carcinoma than that in polyp of vocal cord （P 〈 0.01）, however the expression of Caspase-3 was significantly lower in laryngeal squamous cell carcinoma than that of polyp of vocal cord （P 〈 0.05）. The expressions of Livin and Caspase-3 were significantly different in lymph node metastasis,clinical stage and differentiation （P 〈 0.05）, but no significant differences in cinical classification, smoking history, patients＇ age and gender （P 〉 0.05）. There was a significantly negative correlation between Livin and Caspase-3 （rs=-0.448, P 〈 0.05）. Conclusion： Livin was positively related to Caspase-3, which might play an important role in the carcinogenesis and development of laryngeal carcinoma by synergic effect.
出处
《天津医药》
CAS
北大核心
2012年第12期1206-1209,共4页
Tianjin Medical Journal
