肺炎支原体感染和AECOPD患者临床特征的关系

The Correlation of Clinical Features of Mycoplasma Pneumonia Infection and Acute Exacerbation of Chronic Obstructive Pulmonary Disease

目的:探讨肺炎支原体(Mp)感染与慢性阻塞性肺疾病急性加重期(AECOPD)患者临床特征的关系。方法:收集AECOPD患者298例(实验组),同期其他呼吸道感染患者120例(对照组),对所有入选者进行Mp抗体检测。比较2组的Mp检出率,同时根据Mp检测结果将实验组分为Mp阳性组68例和Mp阴性组230例,比较Mp阳性组和Mp阴性组的临床特征及细菌感染情况。结果:实验组Mp抗体阳性率为22.82%,高于对照组的12.5%,差异有统计学意义(χ2=5.724,P<0.05);轻、中、重、极重AECOPD患者Mp检出率分别为23.63%、23.52%、19.82%、25.81%,差异无统计学意义(χ2=0.512,P>0.05)。Mp感染的发病高峰为7月和12月,Mp的检出率和AECOPD的住院率无相关性(r=0.305,P>0.05)。Mp阳性组发热、咳嗽发生率及胸片表现与阴性组比较差异有统计学意义,2组其他临床特征差异无统计学意义。结论:Mp感染为AECOPD的常见原因,与疾病的严重程度无关,与发病时间有关。

Objective： To explore the correlation between the infection of mycoplasma pneumonia （Mp） and the hospitalization ratio of acute exacerbation of chronic obstructive pulmonary disease （AECOPD）. Methods： The study included 298 patients with AECOPD （experimental group） and 120 patients with other kinds of respiratory i.nfection （control group）. The antibody of Mp was detected and compared in two groups of patients. According to results of the Mp investigation the experimental group was divided into Mp positive group and Mp negative group. The clinical features and bacterial infections were compared between Mp positive group and Mp negative group. Results： The positive rate of Mp antibody was 22.82% in experimental group, which was significantly higher than that of 12.5% in control group （X2= 5.724,P 〈 0.05）. The Mp detection rates were 23.63%, 23.52%, 19.28% and 25.81% in the light, medium, heavy and very heavy AECOPD patients respectively but without significant differences （χ2=0.512,P 〉 0.05）. The peak incidence of Mp infection was found in July and December. There was no significant correlation between the detection rate of Mp and the hospitalization rate of AECOPD（r=0.305, P 〉 0.05）. There were significant differences between fever, cough incidence and chest X-ray findings in Mp positive group, no significant differences in clinical features between other two groups. Conclusion： Mp infection is a common cause of AECOPD, which is related to the time of onset, but not related to the severity of the disease.