不安腿综合征的药物治疗

Pharmacotherapy for restless legs syndrome

不安腿综合征是一种常见的神经系统感觉运动障碍疾病,常伴有睡眠障碍。它可见于任何年龄,因缺乏特异性的实验室辅助诊断依据,大多数患者在发病数年后仍不能被识别,甚至被误诊,更得不到适当治疗。过去的数十年里,多个大型临床研究证实,几种类型的药物可用来改善患者症状,包括多巴胺能药物、抗癫痫药物、鸦片类药物和苯二氮类药物。

Restless legs syndrome （RLS） is a common neurological sensor-motor alsoraer and often associated with a sleep complaint. RLS may begin at any ages. Because of lacking special evidence in laboratory, most of patients are unrecognized or misdiagnosed after symptoms onset years and also not treated properly. Large-scale clinical trials in patients with RLS have indicated that kinds of drugs could be used to improve the symptoms, including dopaminergics, anticonvulsants, opioids and benzodiazepines. This article review therapeutic studies and present it for the practical management of RLS.