芬太尼的滥用及监测管理

Abuse and rational use of fentanyl

目的:了解芬太尼的药理特性及滥用风险,分析其国内的滥用情况,为该药在临床的合理使用及科学监管提供参考。方法:检索国内外芬太尼滥用的文献报道,汇总近年来国内外药物滥用数据中有关芬太尼的数据并进行分析。结果:芬太尼由于其独特的药理特性存在被滥用的可能,文献报告和监测数据表明,自芬太尼上市以来欧美国家相继发生芬太尼滥用现象,北京市也存在芬太尼滥用的监测报告。结论:芬太尼类化合物的不合理使用会带来严重的安全隐患,临床医生、患者、药品监管部门都应当增强对其滥用风险的认识,积极避免不合理用药情况的出现。

Object： To provide information in the clinical rational use and for scientific supervision, by understanding of the pharmacological characteristics and the risk of abuse of fentanyl, and analysis of their abuse at home and abroad Method： We retrievaled fentanyl abuse reports at home and abroad, summarizing and analyzing drug abuse data related to fentanyl in recent years. Reslut： Fentanyl has the potential for abuse due to its unique pharmacologica properties, literature and monitoring data show that fentanyl abuse occurred in Europe and the United States since the fentanyl listed, the report of fentanyl abuse also occurred in Beijing. Conclusion： The irrational use of the fentanyl class will lead to serious risks. Clinicians, patients, drug administration departments should enhance the understanding of its risk of abuse, and actively avoid the occurrence of irrational use, and put an end to the abuse incident.