乳铁蛋白、腺苷脱氨酶和癌胚抗原联合检测在老年患者胸水鉴别诊断中的作用

Combined detection of lactoferrintin, adenosine deaminase and cancer embryo antigen in differential diagnosis of pleural effusion in aged patients

目的 探讨LF、ADA、CEA联合检测对老年患者胸水的鉴别诊断价值。方法 IF和CEA采用放射免疫法 ,ADA采用光电比色法 ,共测定了老年结核性胸水 40例和恶性胸水 46例同时行细胞学检查。结果 LF、ADA、CEA单项检测的诊断准确性分别为 80 %、83 %、82 % ;三项联合检测其中二项或三项同时阳性的诊断准确性分别为 90 %、91%、89%、93 %。结论 胸液LF、ADA。

Objective To evaluate the combined detection of lactoferrintin (LF), adenosine deaminase (ADA) and cancer embryo antigen (CEA) in the differential diagnosis of pleural effusion in aged patients. Methods LF and CEA were determined with immunoradioassay and ADA with photoelectric colorimetry in the pleural effusion of 40 aged patients with pulmonary tuberculosis and 46 cases of malignant disease. Cytological study was also performed. Results The diagnostic accuracy of LF, ADA and CEA was 80%, 83% and 82% respectively when they were used singally to examine pleural effusion and the diagnostic accuracy would the increased when 2 of them or all the 3 were used simultaneously to examine pleural effusion. Conclusion The combined application of LF, ADA and CEA improves the accuracy of differential diagnosis of pleural effusion in aged patients.