参龙降压灵、尼群地平合用对自发性高血压大鼠24h血压的影响

Effect of Shenlong Jiangyaling combined with nifedipin on the 24 h blood pressure of spon-taneous hypertensive rat

目的与方法 观察参龙降压灵、尼群地平合用一次性给药对自发性高血压大鼠24 h血压的影响，并与牛黄降压丸比较。结果 参龙降压灵最大降压幅度(2.65 kPa)稍高于牛黄降压丸(2.03 kPa)，略低于尼群地平(2.92 kPa), 而降压作用时间较后2者持久；参龙降压灵与尼群地平合用，降压作用显著提高，最大降压幅度（5.65 kPa）相当于二者之和，作用时间更持久，明显优于各单味药。结论 参龙降压灵降压作用肯定，与尼群地平合用有显著协同作用。

Objective and Methods To observe the changes of 24 h blood pressure (BP) of spontaneous hypertensive rat (SHR) after administration of Shenlong Jiangyaling combined with nifedipin and to compare the therapeutic effect of this medication with Niuhuang Jiangya pill. Results The maximum reduction in blood pressure induced by Shenlong Jiangyaling (2.65 kPa) was slightly higher than that by Niuhuang Jiangya pill (2.03 kPa), and a little lower than that by nifedipin (2.92 kPa). However, the duration of Bp-reducing effect of Shenlong Jiangyaling is the best. When Shenlong Jiangyaling and nifedipin were combined, significant increase in the amplitude of maximum Bp reduction was observed, equivalent to the total of that induced by each of the drug, and with longer duration of action. Conclusions It is definite that Shenglong Jiangyaling can reduce blood pressure. Combined with nifedipin, the therapeutic can be obviously enhanced.