复方血栓通胶囊对实验性犬缺血心肌的保护作用

Protective effect of compound XueShuanTong capsule on experimental ischemic myocardium of canine

目的 复方血栓通胶囊的功效为活血化淤、益气养阴，既往多用于眼科疾患，但临床也有扩大运用于心血管系统疾病的报道。为了证实其药理作用，我们观察了该药对实验性犬缺血心肌的保护作用。方法 采用结扎冠状动脉左前降支的方法复制急性心肌缺血模型。全程检测血压，实验结束时取左室缺血区心肌检测超氧物歧化酶（SOD）、丙二醛（MDA）、糖原、乳酸、乳酸脱氢酶(LDH) 等生化指标。结果 复方血栓通高、低剂量组血压和SOD活性均显著高于缺血组，与对照组和地奥组比较无显著差异，其MDA、LDH含量均显著低于缺血组，与对照组和地奥组比较无显著差异。结论 复方血栓通胶囊对实验性犬缺血心肌具有保护作用。

Objective To explore the protective effect of compound XueShuanTong capsule on experimental ischemic myocardium of canine. Methods The left anterior descending coronary artery was ligated to make a model of acute myocardial ischemia. Results The blood pressure and SOD activity of low- or high- dose XueShuanTong group were significantly higher than those of ischemia group. The level of MDA and LDH of low- or high- dose XueShuanTong groups were significantly lower than those of ischemia group. Conclusion The compound XueShuanTong capsule can protect ischemic myocardium.