胆汁细菌性感染时血浆内毒素水平的变化

Endotoxin Level in Plasma of Patients with Bile Bacterial Infection

目的 :研究胆汁在不同类型的细菌感染时血浆内毒素含量的变化。方法 :胆囊切除术中取胆汁作细菌培养和涂片染色镜检。革兰氏阴性菌感染者 ( 40例 )、革兰氏阳性菌感染者 ( 40例 )和菌检阴性者 (对照组 4 0例 )共 1 2 0例 ,均在胆囊切除术前后测定血浆内毒素水平。结果 :术前革兰氏阴性菌感染组血浆内毒素水平明显高于革兰氏阳性菌感染组和对照组 (P <0 .0 1 ) ,革兰氏阳性菌感染组与对照组之间无明显差异 (P >0 .0 5) ;术后革兰氏阴性菌感染组血浆内毒素水平很快下降与术前比较有极显著差异 (P <0 .0 1 )。结论 :血浆内毒素定量测定 ,可作为判断胆汁感染轻重程度和观察治疗效果的指标。

Objective To estimate the change of endotoxin level in plasma of patients with bile infection by different types of bacteria.Methods The endotoxin in plasma was tested before and after cholecystectomy;and during the operation,the bile was taken to bacterial culture and smear examination.According to the results of bacteriologcal examination,the cases were divided into three groups:G - group(n=40)—with Gram negative bacterial infection,G + group(n=40)—with Gram positive bacterias infection and contral group(n=40)—without bacterial infection.The levels of plasma endotoxin were measured in all cases of three groups,compared each other and analyzed statistically.Results The level of plasma exdotoxin was significantly higher in G - group than in G + group(P&lt;0.01),and there was no significant difference between the G + group and control group(P&gt;0.05).In G - group,the plasma endotoxin reduced rapidly after operation and its level was obviously different from that before operation(P&lt;0.01).Conclusion The level of plasma endotoxin can be seen an index to reflect the degree of bile infection and the effect of treatment.