纳络酮在重度乙醇中毒中的临床应用

Clinical Practice of Naloxone in Treating Severe Alcohol Poisoning

目的 :观察纳络酮在乙醇急救中的作用。方法 :64例患者均用 50 %葡萄糖液 2 0ml加入纳络酮 0 .8mg静注 ,酌情反复使用 ,最大累计用量不超过 4mg。 结果 :1 8分钟内清醒 4 4例 ,4 5分钟内清醒1 6例 ,90分钟内清醒 4例。 63例抢救成功 ,1例死于急性肺水肿。结论 :纳络酮能迅速逆转乙醇中毒损害 ,疗效肯定。

Objective To observe the effect of naloxone(NLX) in treating alcohol posoning.Methods 64 cases with severe alcohol poisoning were treated with 0.8mg NLX in 20ml of 50% glucose (iv).This administration could be repeated according to patient′s state.The maximum gross dose of NLX≤4.0mg.Results The consciousness of 44 patients had recoverd in 18min,16 in 45min and 9 in 90min.The rescues were successful for 63 cases,only one patient had been dead from acute pulmonary edema.Conclusion NLX can rapidly reverse the damage caused by alcohol poisoning and this effect is affirmative.