去甲万古霉素对44例化疗后中性粒细胞减少的疗效分析

Analyze the Curative Effect of Norvancomicin Using at 44 Patients with Agranulocyte after Chemiotherapy

目的 旨在研究大剂量 化疗后发生中性粒细胞减少(ANC)时用去甲万古霉素加1-2种其他抗生素治疗的疗效及安全性。方法 将74例ANC病人随机分成两组:去甲万古霉素0.8gBid加1-2种其他抗生素,疗程3-13天;单一泰能/三代头孢或联合喹诺酮类、氨基糖甙类3-10天作为对照。结果 两组的临床有效率分别为82.5％、60.0％,痊愈率为45.0％、23.3％。去甲万古霉素组副作用较小。统计学分析表明两组间疗效有显著性差异。结论 去甲万古霉素加1-2种其他抗生素在化疗后粒细胞减少时可作为一线的经验用药,且安全性较高。

Objective To study the cu-rative effect and security of norvancomycin and 1-2 else antibiotics which used at pa-tients occuring agranulocyte (ANC) after high dose chemiotherapy. Methods We divide the 74 ANC patients into two groups randomly: norvancomycin 0. 8g Bid and 1 -2 else antibiotics, period of treatment is 3 -13days; Imipenem/ the third cephalosporins or combining with quinolones, aminoglycosides 3-10 days as contrast Results The clinical effect rates of the two groups are 82. 5%, 60.0%; re- covery rates are 45.0% , 23.3%. The side - effect of norvancomycin group is small. Statistics analysis shows there are marked difference between the two groups. Conclusion Norvancomycin and 1 -2 else antibiotics can be a gleam of experiential medicine, and they are safety.