异烟肼乙酰化代谢昼夜节律性的研究

Study on circadian rhythm of isoniaxid acety lated metabolism

目的与方法 :本文对 6名健康自愿者和 6名结核病人进行了异烟肼乙酰化代谢比率(MR)进行了研究。结果 :表明 MR具有极明显的昼夜节律性 (P<0 .0 1)。表现为下午 15∶ 0 0服药 MR最大 ,早晨 6∶ 0 0和晚上 2 2∶ 0 0服药 MR最小 ,两者比较具有显著性差异 (P<0 .0 1)。结论 :由此推测人体内 N-乙酰转移酶的活性具有明显的昼夜节律性 。

Objective and method [WT5BZ]: This article is about the study on circadian rhythm of isoniazid acetylated metabolism for six healthful volunteers and six phthisics.[WT5HZ]Result:[WT5BZ]The result indicates that the rate of isoniazid acetylated metabolism(MR)has a very manifest circadian rhythm.(P<0.01).It shows:Administration at p.m 15∶00,MR is the biggest;MR is the smallest when administration is at a .m 6∶00 or p.m 22∶00.There is a significant difference between them(P<0.01).Conclusion:According to the results,we guess that the activity of N acetyltransferase in human body has a manifest circadian rhythm. [WT5HZ]