5α-还原酶抑制剂对镍钛记忆合金网状支架治疗BPH远期疗效的影响

Effects of 5α-reductase Inhibitors to the Long-term Effectiveness of Endourethral Wallstent Scaffold in the Treatment of BPH

目的:评估5α-还原酶抑制剂对镍钛记忆合金网状支架治疗前列腺增生(BPH)远期疗效的影响。方法:287例年龄62-90岁(平均年龄75.7岁)前列腺增生症患者接受镍钛记忆合金网状支架置入术治疗,服药组接受5α-还原酶抑制剂治疗超过12月,对照组接受5α-还原酶抑制剂治疗不足12月,于术后12月、24月、36月、48月、60月进行随访。结果:随着治疗时间的延长,各组治疗的有效率呈进行性下降,5α-还原酶抑制剂服药组术后60月有效率为62.5%,对照组术后60月有效率为52.1%,具有统计学差异(P<0.05)。结论:给予5α-还原酶抑制剂治疗可有效改善镍钛记忆合金网状支架置入术治疗患者的远期疗效。

Objective： To evaluate the effect of 5α-reductase inhibitors to the long-term effectiveness of endourethral wallstent scaffold in the treatment of BPH.Method： Total of 287 BPH patients with mean age 75.7 years（62-90 years） who underwent selfexpanding flexible endourethral wallstent were retrospectively analyzed.Treatment group was treated with 5α-reductase inhibitors over 12 months;control group was the patients were treated with 5α-reductase inhibitors less than 12 months.They were followed up at 12th,24th,36th,48th and 60th month post-operatively.Result： With the extension of treatment,the efficiency decreased progressively.At the 60th month post-operatively,the effective rate was 62.5% and 52.1% respectively in the treatment group and control group.Conclusion： 5α-reductase inhibitors could effectively improve the long-term effectiveness of endourethral wallstent scaffold in the treatment of BPH.