CD105在甲状腺乳头状癌组织中的表达与VEGF-C的关系被引量：1

下载PDF

导出

摘要目的:研究探讨CD105在甲状腺乳头状癌组织中的表达与VEGF-C表达的相关性。方法:采用免疫组化S-P方法检测56例PTC和22例结节性甲状腺肿组织中的CD105、VEGF-C的表达,并计数CD105标记的MVD值。结果:以CD105标记的PTC组织中MVD值及VEGF-C的表达与结节性甲状腺肿组织间差异有统计学意义(P<0.01)。MVD值与VEGF-C表达呈正相关(P<0.01)。且与淋巴结转移、TNM分期有关(P<0.01)。结论:CD105与PTC的微血管形成、淋巴结转移密切相关。提示PTC标本中CD105、VEGF-C的联合检测可以为患者预后提供有价值的信息。

作者杨智王泉海王天武王东生张万军王运转吴晓何金嵘

机构地区河北省邯郸市磁县肿瘤医院河北省邯郸市第四医院外二科河北省邯郸市峰峰集团四矿医院河北省武安市徘徊中心卫生院河北省邯郸市峰峰矿区妇幼保健站河北省邯郸市峰峰矿区中医院

出处《河北医学》 CAS 2013年第1期108-111,共4页 Hebei Medicine

关键词甲状腺癌血管内皮生长因子淋巴结转移 CD105

分类号 R736.1 [医药卫生—肿瘤]

引文网络
相关文献

参考文献11

1Weidner N. Current pathologic methods for measuring intra-tumoral microvessel density within breast carcinoma and oth-er solid tumors[ J]. Breast Cancer Res Treat, 1995,36 (2):168-180.
2Folkman J. What is the evidence that tumors are angiogene-sis dependent[ J]. Natl Cancer Inst,1.90,82:4-6.
3Fonsatti E, Maio M. Highlights on endoglin( CD105 ) : frombasic findings towards clinical applications in human cancer[JJ.Transl Med,2004,2: 18.
4Minhajat R, Mori D, Yamasaki F, et al. Organ - specific en-doglin ( CD105 ) expression in the angiogenesis of humancancers. Pathol Int,2006,56:717-723.
5Erdem 0,Taskiran C,Onan MA,et al. CD105 expression isan independent predictor of survival in patients with endome-trial cancer[ J]. Gynecol Oncol,2006,103 : 1007-1011.
6Akagi K, Ikeda Y, Sumiyishi Y,et al. Estimation of angio-genesis with anti- CD105 immunostaining in the processs ofcolorectal cancer development [ J]. Surgery, 2002, 131(Suppl) : S109-113.
7Li C. CD105 is a biomarker for colorectal cancer prognosis[J]. Cancer Weekly,2003,7:42-43.
8Nikiteas NI,Tzanakis N,Theodoropoulos G,et al. Vascularendothelial growth factor and endoglin ( CD105 ) in gastriccancer[ J]. Gastric Cancer,2007,10: 12-17.
9Hashimoto I, Kodama J, Seki K, et al. Vascular endotheli-cal growth factor - C expression its relationship to pelviclymph node status in invasive cervical cancer[ J]. Br Canc-er,2001,85( 1) :93-97.
10王金胜,冯德云,彭劲武,曾庆富.血管内皮生长因子C在甲状腺癌组织中的表达及其意义[J].实用癌症杂志,2004,19(4):375-376. 被引量：3

二级参考文献8

1Fromowitz FB,Viola MV,Chao S,et al.ras p21 expression in the progression of breast cancer[J].Hum Pathol,1987,18(12):1268.
2Oh SJ, Jeltsch MM, Birkenhager R, et al. VEGF and VEGF-C:specific induction of angiogenesis and lymphangiogenesis in the differentiated avian chorioallantoic membrane[J].Dev Biol,1997,188(1):96.
3Lymboussaki A,Partanen TA,Olofsson B,et al.Expression of the vascular endothelial growth factor C receptor VEGFR-3 in lymphatic endothelium of the skin and in vascular tumors[J].Am J Pathol,1998,153(2):395.
4Bunone G,Vigneri P,Mariani L,et al.Expression of angiogenesis stimulators and inhibitors in human thyroid tumors and correlation with clinical pathological features[J].Am J Pathol,1999,155(6):1967.
5Tsurusaki T,Kanda S,Sakai H,et al.Vascular endothelial growth factor-C expression in human prostatic carcinoma and its relationship to lymph node metastasis[J].Br J Cancer,1999,80(1～2):309.
6Yonemura Y,Fushida S,Bando E,et al.Lymphangiogen-esis and the vascular endothelial growth factor receptor(VEGFR)-3 in gastric cancer[J].Eur J Cancer,2001,37(7):918.
7Ohta Y,Shridhar V,Bright RK,et al.VEGF and VEGF type C play an important role in angiogenesis and lymphangiogenesis in human malignant mesothelioma tumours[J].Br J Cancer,1999,81(1):54.
8董昕,邱雪杉,王恩华,李庆昌,顾伟.血管内皮生长因子C及其受体3在非小细胞肺癌组织中的表达及意义[J].中华病理学杂志,2003,32(2):128-132. 被引量：58