低能电子致DNA链断裂的纳剂量蒙特卡罗模拟

Nanodosimetry Monte Carlo simulation of DNA strand breaks by low-energy electron

为了对DNA损伤进行纳剂量蒙特卡罗模拟,先根据D.Emfietzoglou给出的介电响应理论和Born修正模型计算了低能电子与液态水的非弹性反应截面,在Geant4-DNA的基础上建立了纳剂量蒙特卡罗程序的物理模块,同时参照国际纳剂量蒙特卡罗程序使用的模型参数建立了纳剂量蒙特卡罗程序的前化学模块、化学模块、DNA几何模块及DNA损伤模块。利用本程序,采用H.Nikjoo给出的对电子均匀照射DNA情形的模拟方法,还模拟计算了不同能量电子均匀照射DNA所导致的DNA链断裂产额,并与已公布的实验数据进行比对,二者符合良好。

In order to simulate the yields of low-energy electrons induced DNA strand breaks, according to D. Emfietzo- glou＇s dielectric response theory and Born＇s correction model, we calculated the inelastic reaction cross sections for low-energy e- lectron transport in liquid water. The physic module on the basis of the Geant4-DNA was established, and also the pre-chemical, chemical, DNA damage analysis modules were established. The yields of DNA strand breaks caused by the different energy elec- trons uniformly irradiating DNA were simulated, and the simulation results are in good agreement with the published experimen- tal data.