电离辐射与细胞动力学

Ionizing radiation and cell kinetics

细胞对电离辐射的反应取决于 DNA的损伤程度及细胞对此损伤的修复能力 ,损伤后修复能力和损伤性质因细胞周期而异。因此 ,细胞动力学改变是影响放射治疗效果的重要因素。随着放射生物学研究的进展 ,细胞动力学改变与修复的分子基础逐渐被揭示出来 ,并表现出许多明显的共同点。近年来有关放射治疗的分子生物学研究成果 。

Cell responses to ionizing radiation are determined by extent and repair capability of DNA damage. Capability of DNA damage repair and character of damage vary as a function of cell cycle. Thus cell kinetics alteration is the principal factor that influences the effect of radiotherapy. With advancement in radiobiology, the respective molecular mechanisms underlying cell kinetics alteration and DNA damage repair is being revealed gradually and takes on many obvious similarities. We review the recent achievements relevant to radiotherapy in molecular biology to show potential relationships among them.