1-氧代-1-(6-甲氧基-2-萘基)-2-溴丙烷的合成

Synthesis of-1 Oxo-2-bromo-1-(6-methoxy-2-naphthyl) propane

通过滴加溴化铜的甲醇溶液 ,6-甲氧基 -2 -丙酰萘在均相体系中回流 ,可高选择性地溴化 ,得到合成非甾体消炎镇痛药萘普生的关键中间体 1-氧代 -1-( 6-甲氧基 -2 -萘基 ) -2 -溴丙烷 ,收率 92 .8%

Oxo 2 bromo 1 (6 methoxy 2 naphthyl) propane was obtained by bromination of 6 methoxy 2 propionylnaphthalene with cupric bromide in methanol with 92.8% yield.