摘要
研究了1,8-辛二醇在四氢呋喃溶剂中,吡啶为缚酸剂和乙酸酐进行单边乙酰化反应制备8-乙酰氧基-1-辛醇。通过改变反应温度、反应时间、反应物配比和吡啶的用量等因素研究了1,8-辛二醇单边乙酰化的最佳制备工艺条件:溶剂为二氯甲烷、反应温度为0℃、反应时间为4.5 h、乙酸酐和1,8-辛二醇的摩尔比为0.95:1、傅酸剂吡啶的用量为乙酸酐1.2倍量(摩尔比)。在最佳工艺条件下,气相分析单边乙酰化的收率为82.7%。
8 - acetoxyo - 1 - octanol was synthesized from 1, 8 - octanediol by monoacetate reaction with acetic an-hydride using pyridine as acid binding agent in tetrahydrofuran. The influences of the reaction temperature, the reaction time, the molar ratio of acetic anhydride to 1, 8 - octanediol and the quantity of pyridine on the yield of 8 - acetoxyo - 1 -octanol were investigated. The optimum reaction conditions were reaction temperature 0 ℃, eaction time 4. 5 h, n ( acetic anhydride)/n( 1,8 - octanediol) = 0. 95, and n ( pyridine )/n ( acetic anhydride ) = 1.2. Under the optimum conditions, the yield of 8 - acetoxyo - 1 - octanol was 82. 7% by GC.
出处
《广州化工》
CAS
2012年第23期52-54,共3页
GuangZhou Chemical Industry
基金
嘉兴学院重点SRT项目(项目编号:851712010)
嘉兴市科技局资助项目(项目编号:2012AY10)
浙江省博士后科研项目择优资助(项目编号Bsh120268)