三七中人参皂甙对老年鼠血液中抗氧化酶活力影响的研究

A Preliminary Study on the Relationship between the Effect of Panax Notoginsen R b1 R g1 on the Aging Process

对 58例实验小鼠模型的研究以期为三七中人参皂甙单体Rb1及Rg1的抗衰老作用提供实验依据 ,探讨其抗衰老的机理 . 2 0月龄抗衰老实验组小鼠分别按 90mg/kg体重给予三七人参皂甙Rb1,Rg1,连续给药 30d ,断头取血测定红细胞超氧化物歧化酶 (SOD)及过氧化氢酶 (CAT) .结果表明 :两种人参皂甙均能显著提高SOD和CAT活力 .Rb1给药组SOD为 ( 588 30± 79 4 7) μg/gHb ,与衰老组 ( 4 14 75± 37 88)比较x升高 4 1 8% ;而Rg1给药组为 ( 62 9 0 8± 96 88) μg/gHb ,x升高 51 68% .两者均P <0 0 1,差异非常显著 .Rb1及Rg1组都提高CAT活力 10 %以上 ,P <0 0 5.说明均具有较强的抗氧化作用 。

R b1, R g1 extracted from panax notoginsen could increase the activity of superoxide dismutase(SOD) and catalase(CAT) in white blood cell. The activity of SOD increased 41 85% against the control group while that of R g1 increased 51 68%. The increased activity of CAT in aging mouse was 10%.