基于Disector技术的突触数密度计算机辅助分析系统

A Computer-aided Analysis System for Counting the Synaptic Numerical Density Based on Disector Technique

突触数目的改变在神经系统的各种生理病理过程中具有重要的意义。数密度是形态计量学中衡量空间中某种粒子数目多少的结构参数。作为新兴的体视学技术Disector技术已广泛应用于生物组织中粒子数目的计数，它是利用已知距离的相邻平行切片计数三维空间中任意粒子数目的体现学方法。我们探讨在Window95平台上，采用VisualBasic4．0为开发工具，实现基于PhysicalDisector技术的突触数密度的计算机辅助分析。

The change in the numbers of synapse is of importance in various kinds of physiological and pathological processes. The numerical density is the structural parameter measuring up the numbers of the particles in the space. A new stereological technique, the disector technique, has been described to count the number of particles in a given volume of tissue. It is a technique for counting the number of arbitrary particles in 3-dimensional space using adjacent parallel sections at known distance apart. In this article also discussed is the software for computer assisted count of the synaptic numerical density based on the physical disector technique with Visual Basic 4.0.