围手术期血浆神经肽Y、神经降压素、内皮素-1、降钙素基因相关肽水平的变化

CHANGES OF PLASMA NPY NT ET-1 CGRP LEVELS IN PATIENTS WITH GASTROINTESTINAL CARCINOMAS DURING PERIOPERATIVE PERIOD

选择胃肠癌患者，分别取术前、术中、术后第１、７天静脉血，用放射免疫分析测定血浆神经肽Ｙ（ＮＰＹ）、神经降压素（ＮＴ）、内皮素－１（ＥＴ－１）、降钙素基因相关肽（ＣＧＲＰ）浓度。结果表明；ＮＰＹ浓度，术中高于术前（Ｐ＜０．０１），术后第１、７天均低于术前（Ｐ＜０．０１）。ＮＴ浓度，术中低于术前（Ｐ＜０．０５），术后第１天低于术前（Ｐ＜０．０１）。ＥＴ－１浓度，术中和术后降低（Ｐ＜０．０１）。ＣＧＲＰ浓度，术后第１天升高（Ｐ＜０．０１）。术前ＥＴ－１与ＣＧＲＰ负相关（Ｐ＜０．０１），ＥＴ－１／ＣＧＲＰ－１．４，术中为０．８２，术后第１天和第７天分别为０．８４、１．３６。提示：围手术期血浆中４种肽类物质参与了围手术期维持血流动力学稳定的调节，是创伤与应激时的病理生理改变的重要组成部分。

Blood samples were obtained from patients with gastrointestinal carcinomas before operation, dur- ing operation, and 1st and 7th day after operation. The NPY NT ET-1 CGRP concentrations were determined by radioimmunoassay. The results showed that the NPY levels were higher during operation and lower after operation than those before operation (P<0. 01). The NT levels were lower during operation (P<0. 05) and on the first postoperative day (P<0. 01) and on the 7th postoperative day(P>0. 05) than those of preoperation. The ET-1 and CGRP levels were negatively correlated (r=-0. 51, P<0. 01). ET-1/CGRP Ratio was 1. 4. The ratio de- creased during operation (0. 82) and on the 1st postoperative day (0. 84) and increased again on the 7th postopera- tive day (1. 36).