人膀胱癌多药耐受相关蛋白基因表达的意义

EXPRESSION OF MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN GENE IN HUMAN BLADDER CANCER

为研究多药耐受相关蛋白基因（ＭＲＰ）在人膀胱癌中的表达状况，采用免疫组化技术检测４７例初发膀胱癌，７例复发性膀胱瘤及７例正常膀胱粘膜组织标本ＭＲＰ的表达。结果显示初发膀胱癌中，ＭＲＰ总阳性率为 ４０． ４％，复发性膀胱癌 ＭＲＰ总阳性率为 ５７．１％，正常膀胱粘膜也有 ２８． ５％的表达率。高分级（Ｇ_３）膀胱癌较低、中分级（Ｇ_１、Ｇ_２）膀胱癌 ＭＲＰ表达阳性率显著降低。说明 ＭＲＰ表达率下降是肿瘤分化不良及恶化的结果。ＭＲＰ与ｍｄｒ１表达之间无明显关系，两种基因不存在共同调节，进一步研究这种差异的临床意义是很有必要的。

To study the expression of multidrug resistance-associated protein in bladder cancer. The multidrug resistance-associated protein (MRP) expression was determined using immunohistochemistry in s pecimens and in 7 normal bladder mucosa as control. The MRP positive rate in primary bladder cancers was 40. 4%, and in recurrent bladder cancer was 57. 1%. The MRP expression positive rate in a grater proportion of high-grade (G_3) bladder cancer was significantly reduced compared with low- and moderate-grade (G_1,G_2 ) bladder cancer. Results indicate that positive MRP expression was frequently reduced as a consequence of tumor progression and poor differentia- tion. No correlation was found between MRP and mdr1 expression. Further studies are required to establish its clinical significance.