支气管动脉灌注诺维本治疗非小细胞肺癌46例的近期疗效

Bronchial Arterial Infusion of Navelbine in the Treatment of Non-small Cell Lung Cancer A Report of 46 Cases

目的 :探讨经支气管动脉灌注诺维本加顺铂治疗非小细胞肺癌的疗效、安全性和并发症的防治。方法 :全组46例 ,男性38例 ,女性8例 ;年龄24～72岁。病理类型 :鳞癌23例 ,腺癌20例 ,腺鳞癌3例。Ⅲa期6例 ,Ⅲb期28例 ,Ⅳ期12例。结果 :完全缓解4例 ,部分缓解30例 ,稳定8例 ,进展4例 ;总有效率76.1%。并发症共21例(45.7% ) ,其中肋间动脉炎18例 (39.1 % ) ,食管损伤4例 (8.7 % ) ,除食管支气管瘘1例死于大咯血外 ,所有并发症均治愈。结论 :经支气管动脉灌注诺维本加顺铂治疗非小细胞肺癌安全、有效率高 ;并发症多可防治。

Objective: To evaluate the effect of combin-ation chemotherapy with Navelbine plus Cisplatin via bronchial arterial infusion in the treatment of non-small cell lung cancer (NSCLC). Methods: Forty-six cases of NSCLC including 38 males and 8 female patients were enrolled. The age of the patients ranged from 24 to 72 years.Squamous cell carcinoma and adenocarcinoma predominatede . Six cases were of stage Ⅲa , 28 stage Ⅲb and 12 stage Ⅳ diseases. Results:Of this series complete response was observed in 4 cases, partial response 30,stable disease 8,and progressive in 4 cases. The overall response rate was 76.9%. Complication occurred in 21 cases (45.7%) including intercostal arteritis 18 (39.1%),esophageal injury 4 (8.7%) with one case of esophago-trachial fistula who died of hemoptysis choke. Conclusion: NSCLC treated by Navelbine plus Cisplatin via BAI is effective with a high response rate, and most of the complications could be circumvented and prevented.