摘要
目的寻找与胃癌发生有密切关系的肠上皮化生的类型,为胃癌早期诊断提供可靠的理论依据。方法应用AB-PAS、HID-AB粘液组织化学方法,区别癌旁组织和背景粘膜组织伴有肠上皮化生的类型。结果 ①39例胃癌组织当中,癌旁伴有肠上皮化生的为31例,背景粘膜伴有肠上皮化生的为25例。②癌旁肠上皮化生的AB-PAS染色, 100%阳性; HID-AB染色,87.1%阳性。背景粘膜肠上皮化生AB-PAS染色, 100%阳性; HID-AB染色, 40%阳性。③31例癌旁组织的肠上皮化生中,74.2%为不完全大肠型;25例背景粘膜的肠上皮化生当中,52%为不完全小肠型和32%为不完全大肠型。结论癌旁组织的不完全大肠型肠上皮化生与胃癌的发生有密切关系。背景粘膜组织当中的小灶状不完全大肠型肠上皮化生,具有潜在发生癌变的可能性。
Objective To study the relationship between intestinal metaplasia(IM) and gastric carcinoma. Methods Two mucin histochemical techniques, alcian blue-pH2.5-periodic acid-schiff(AB-PAS) and highiron-diamine-alcian blue-pH2. 5(HID-AB) were applied to differentiate the type of IM in adjacent mucosa and background mucosa of gastric carcinoma. Results ①Among 39 cases of samples, the adjacent mucosa was accompanied by IM in 31 cases, the background mucosa was accompanied by IM in 25 cases; ②IM in the adjacent mucosa, positive rate was 100% with AB-PAS, 87. 1% with HID-AB. IM in the background mucosa, positive rate was 100% with AB-PAS, 40% with HID-AB; ③Among 31 cases of IM in the adjacent mucosa, incomplete colonic type accounted for 74. 2%. Among 25 cases of IM in backgroung mucosa, incomplete small intestinal type accounted for 52%, incomplete colonic type 32%. Conclusion Incomplete colonic type of IM in the adjacent mucosa has a close relationship with the development of gastric carcinoma, and spot incomplete colonic type of IM in the background mucosa has an underlying possibility to develop cancer.
出处
《哈尔滨医科大学学报》
CAS
2000年第3期160-162,共3页
Journal of Harbin Medical University
基金
归国留学基金!资助项目(9800679)
黑龙江省自然科学基金!资助项目(D9847)
关键词
肠上皮化生
胃癌
癌旁组织
染色法
intestinal metaplasia
gastric carcinoma
adjacent mucosa of gastric carcinoma
staining