老年SBI、SBI性痴呆患者血浆ET、CGRP含量分析

The Hvels of Plamsa ET CGRP Alteration in Old Patients with SBI and SBI Dementia

目的分析老年无症状性脑梗塞（ＳＢＩ）、ＳＢＩ痴呆发病与血浆内皮素（ＥＴ）、降钙素基因相关肽（ＣＧＲＰ）含量关系。方法经临床与头颅 ＣＴ或 ＭＲＩ扫描检查确诊的 ４２例 ＳＢＩ和 １８例 ＳＢＩ性痴呆患者。晨间取肘静脉血５毫升、ＥＤＴＡ二钠抗凝，分离血浆－２０℃下采用免疫分析（ＲＩＡ）法统一检测。结果４２例ＳＢＩ和ＳＢＩ性痴呆组血浆ＥＴ和ＣＧＲＰ分别以５９.７１、８７．２３、５０７４、４１．２１高于或低于对照组的 ５０．１８、５７．４６，两者差异显著； Ｐ <０.０５～０．０１。 ＳＢＩ性痴呆组ＥＴ的增高和ＣＧＲＰ的降低较ＳＢＩ组显著， Ｐ <０．０１。结论 ＥＴ增高、ＣＧＲＰ降低与 ＳＢＩ及ＳＢＩ痴呆的发病密切相关，如能早期有效地防治 ＳＢＩ，将能降低ＳＢＩ性痴呆的发病率。

objective: To study the plasma levels of ET-1 and CGRP in the patients with SBI and SBI dementia, to research the method of prevation and treatment in early stage. Method: The patients were clinical confirmed in diagnosis, and inspected with CT MRI, there were 42 cases of SBI and 18 cases SBI dementia. We took elbow venous blood 5ml on morning,EDTANa2 as anticoagulant,welasmaET-1 and CGRP were assayed with RIA Qt-20℃. Rsults: Plasma ET and CGRP in the patients with SBI and SBI dementia were 59.71, 876.23, 50.74, 42.21 respecratly which were higher and lower than the levels in patients of controul groups significantly P<0.05-0. 01,ET-1 and CGRP in the groups of patients with dewmentia was varied ignificantly P<0.05. Conclusion: increased ET and lecreased CGRP were related to SBI and SBI dementia, if we could effective treat cure the disease, we will the rate of SBI dementia will decrease.