血脂达标后长期降脂治疗方法的探讨

To study the lowing-lipid therapy for who had achieved the low-density lipoprotein cholesterol goal

目的 :观察隔晚服用瑞舒伐他汀10 mg的疗效,探讨血脂达标后的后续治疗方案。方法:选取我院2008年5月至2010年5月,LDL<2.59 mmol/L的75岁以下稳定心绞痛患者共100例,常规服用瑞舒伐他汀10 mg/晚,1个月后随机分为两组:常规组(瑞舒伐他汀10 mg/晚)和试验组(瑞舒伐他汀10 mg/隔晚),随访6个月,观察患者的依从性、LDL的变化。结果:共有16例患者退出,实际入选84例,其中常规组41例,试验组43例,基线LDL水平(2.40±0.17)mmol/L。服用瑞舒伐他汀1个月后,LDL平均降低了(0.33±0.22)mmol/L,降低了13%。6个月,常规组降低了(0.51±0.19)mmol/L,降低了21.3%,治疗组(0.48±0.20)mmol/L,降低了19.6%,两组之间差异无统计学意义。结论:血脂达标后,隔晚服用常规剂量的瑞舒伐他汀,可以有效地降低LDL水平,增加患者依从性。

Objective：To observe the efficacy of 10mg rosuvastatin alternate night,and discusses the subsequent therapy for who had attained the LDL goal.Methods： 100 stable angina cases were elected whose LDL level lower than 2.59 mmol/L,and age lower than 75 years old during May 2008 to May 2010.After a month washout period（10mg rosuvastin per night）,random divided into two groups,routine group who has 10mg rosuvastatin every night,and trial group instead 10mg rosuvastatin every other night,followed up half a year,to observe the change of compliance,and the level of LDL.Results： 84 patients finished while 16 case removed,including 41 patients in routine group and 43 in trial group,the baseline level of LDL was（2.40±0.17）mmol/L.After A month washout period,the LDL level decreased（0.33±0.22）mmol/L,about 13 percent.After half a year,（0.51±0.19）mmol/L was decreases in routine group,about 21.3 percent,while other group was（0.48±0.20）mmol/L,about 19.6 percent,there are on statistic difference.Conclusion： For those who had attained LDL goal has 10mg rosuvastatin alternate night can decrease the LDL level effetely,and increase the patient compliance.