替比培南匹伏脂的体外抗菌作用研究

In vitro activities of tebipenem pivoxil against clinical isolates

目的评价替比培南匹伏脂的体外抗菌作用。方法用琼脂对倍稀释法测定替比培南匹伏脂对519株临床分离菌的体外抗菌活性。结果对革兰阳性球菌中的肺炎链球菌、化脓性链球菌及对甲氧西林敏感的金葡菌和凝固酶阴性的葡萄球菌,替比培南匹伏脂均显示良好的抗菌活性。尤其是对青霉素不敏感肺炎链球菌,替比培南匹伏脂的MIC50最低,为0.25 mg·L-1。本品对流感嗜血杆菌、卡他莫拉菌、产ESBLs和不产ESBLs的肺炎克雷伯菌和大肠埃希菌、易产诱导酶的阴沟肠杆菌、产气肠杆菌、枸橼酸杆菌、粘质沙雷菌的MIC50为≤0.03～5.00 mg·L-1,低于其他5种抗菌药物。结论替比培南匹伏脂对社区感染中常见病原菌有较好的抗菌活性。

Objective To evaluate the in vitro activity of tebipenem piv- oxil. Methods The minimum inhibitory concentrations （MICs） of tebi- penem pivoxil against 519 strains of recent clinical isolates were deter- mined and compared with selected comparators by means of agar dilution. Results For gram -positive aerobic pathogens, tebipenem pivoxil showed satisfied in vitro activity against methicillin susceptible Staphylo- coccus aureus （MSSA） , methicillin susceptibel Staphylococcus coagulase negative （MSSCON） , Streptococcus pneumoniae and Streptococcus pyogenes, especially in penicillin non - susceptible Streptococcus pneu- moniae. MICs0of tebipenem pivoxil（ ≤〈0.25 mg . L≤） was the lowest in 6 comparators. MIC90 of tebipenem pivoxil to Haemophilus influenzae, Moraxella catarrhalis, non- ESBLs Escherichia coli and Klebsielle, ESBLs Escherichia coli and Klebsielle, Enterobacter cloacae, Enterobacter aerogenes, Serratia marcescens, Citrobacter spp. were ≤ 0. 03 - 0.50 mg .L-1. The antibacterial activity of tebipenem pivoxil showed the same or 1/4 MIC9o of meropenem, have good antibacterial activity for 4 compa- rators. Conclusion Tebipenem pivoxil is an effective antibiotic to com- mon pathogenic bacteria infection in the community.