摘要
Transcription factors are a group of regulatory proteins that bJind to specific DNA sequence in the promoter region of the target genes to regulate gene expression at transcriptional level （Baeuerle, 1991; Jackson, 1992）. Transcription factor activator protein-1 （AP-1） is one of the transcription factors initially identified from mammals. The mammalian AP-1 complex contains multiple members of Jun, Fos, ATF which form homo- or heterodimers to perform the regulatory function （Halazonetis et al., 1988; Angel and Karin, 1991; Karin et al., 1997; Jochum et al.. 2001： Veselv et al.. 2009： Shaulian. 2010）.
Transcription factors are a group of regulatory proteins that bJind to specific DNA sequence in the promoter region of the target genes to regulate gene expression at transcriptional level （Baeuerle, 1991; Jackson, 1992）. Transcription factor activator protein-1 （AP-1） is one of the transcription factors initially identified from mammals. The mammalian AP-1 complex contains multiple members of Jun, Fos, ATF which form homo- or heterodimers to perform the regulatory function （Halazonetis et al., 1988; Angel and Karin, 1991; Karin et al., 1997; Jochum et al.. 2001： Veselv et al.. 2009： Shaulian. 2010）.
基金
supported by a grant from the National High Technology Research and Development Program of China (863 Program)(No.2008AA092602)
