HGF、c-Met鼻内翻性乳头瘤恶变中的表达变化及其意义

Expressions and significances of HGF and c-Met in the malignant transformation of nasal inverted papilloma

目的:分析肝细胞生长因子(HGF)与其受体(c-Met)在不同期鼻内翻性乳头瘤中的表达变化,探讨其在鼻内翻性乳头瘤恶变中的作用。方法:选择我院2005年1月至2010年12月间确诊为鼻内翻性乳头状瘤的55例及鼻腔恶性乳头状瘤30例作为实验对象,所有患者均行内镜下切除病变组织,对手术切除组织采用免疫组织化学方法SP法检测HGF、c-Met的表达,并统计其染色得分,比较鼻内翻性乳头瘤组织、癌旁组织与恶性组织的HGF、c-Met表达。分析不同分型的鼻内翻性乳头瘤的HGF、c-Met的表达变化。结果:HGF、c-Met在鼻内翻性乳头瘤组织、癌旁组织与恶性组织中的表达变化一致,均为恶性组织高于鼻内翻性乳头瘤组织与癌旁组织,癌旁组织的表达最低。鼻内翻性乳头瘤的T1期HGF表达明显低于T3期(P<0.05),T4期(P<0.01),c-Met表达T1期明显低于T3、T4期(P<0.01)。结论:HGF、c-Met在鼻内翻性乳头瘤中的表达与其不同分期有关,HGF、c-Met可能促进鼻内翻性乳头的恶变。

Objective To analysis the expressions of HGF and c-Met in different stages of intranasal inverted papilloma and try to explore the effects of HGF and c-Met in the malignant transformation of nasal inverted papilloma. Methods 30 cases with confirmed malignant papilloma and 55 cases with nasal inverted papilloma in our hospital from Jan 2005 to Dec 2010 were received as experimental objects. All the patients underwent endoscopic removal of diseased tissue. The expressions of HGF and c-Met in nasal inverted papilloma tissue, adjacent tissues and malignant tissues were determined by immunohistochemical method, and the stain score of each sample was calculated. The expressions of HGF and c-Met in different stages of nasal inverted papilloma were analyzed. Results The staining scores of H（;F and 〈..-Met in malignant tissue were higher than those in nasal inverted papilloma tissues and tile adjacent tissues, the expressions of HGF and c-Met in the adjacent tissues were the minimum. Expressions of HCF and c-Met in T1 stage of inverted papilloma were significantly lower tban those in T3 stage （P 〈 0.05, P 〈 0.01） and T4 stage （both P 〈 0.01）. Conclusions The expressions of HGF and c-Met in nasal inverted papilloma were related to its stage, and may contribute to the malignant transtormation of it.