鲍曼不动杆菌1433株对碳青霉烯类药物的耐药情况分析

Analysis of the resistance of 1433 strains of Acinetobacter baumanii to carbapenems

目的:对1433株鲍曼不动杆菌对碳青霉烯类药物的耐药情况进行分析,为临床治疗提供参考。方法:对我院2008-2011年自临床标本分离出的1433株非重复鲍曼不动杆菌药敏情况进行回顾性分析,用梅里埃Vitek2分析仪对菌株进行测定及药敏实验,碳青霉烯类包括亚胺培南和美洛培南两种药物,用Whonet5.5软件分析数据,按CLSI2011年版判读药敏结果,统计学处理采用χ2检验。结果:2008-2011年对亚胺培南和美洛培南的总耐药率分别为27.5%,32.5%,37.0%和38.2%;对亚胺培南的耐药率分别为27.9%,32.4%,37.2%和38.6%;对美洛培南的耐药率分别为27.1%,32.7%,36.9%和37.8%。2011年494株鲍曼不动杆菌有4株表现为对亚胺培南耐药,美洛培南敏感,占当年总株数的0.01%。结论:2008-2011年鲍曼不动杆菌对亚胺培南和美洛培南的耐药率有逐年增加的趋势。

Objective To investigate the resistance of 1 433 strains of Acinetobacter baumanii （A. baumannii） strains to carbapenems. Methods A total of 1 433 clinical isolates of non-duplicate A. baumannii were collected from 2008-2011. The susceptibility testing of A. baumannii to imipenem and meropenem were carried out by means of minimal inhibitory concentration （MIC） and by Vitek2 automated microbial identification system. The data were analyzed by WHO-net 5.5 software based on CLSI 2011 breakpoint. Results The resistant rates of A. baumannii to imipenem and meropenem in 2008, 2009, 2010 and 2011 were 27.9%, 32.4%, 37.2%, 38.6%, respectively, and 27.1%, 32.7%, 36.9%, 37.8%, respectively. 4 of 494 strains （0.01%） of A.baumannii in 2011 were resistant to imipenem and susceptible to meropenem. Conclusion The resistant rates of A.baumannii to carbapenems were increased gradually from 2008 to 2011.