新型钙增敏剂MCI-154对失血性休克动物心肌的保护作用

Protective function of a new calcium sensitizer MCI-154 on myocardium of hemorrhagic shock animals

目的 研究新型钙增敏剂MCI- 15 4对失血性休克动物心肌功能与结构改变的影响 ,明确MCI- 15 4对失血性休克的治疗作用。 方法 用家兔和大鼠两种动物制作失血性休克模型 ,设立MCI- 15 4治疗组和等渗盐水对照组 ,监测家兔心肌血流动力学指标 ,测定大鼠血浆CK-MB和LDH并观察大鼠心肌细胞结构的变化。 结果 MCI - 15 4治疗后LVSP、+dp/dtmax、Lo和Vpm等较对照组均有非常显著的升高、LVEDP显著降低 ;CK -MB、LDH的活性非常显著地低于对照组 ;心肌细胞结构损伤程度明显轻于对照组。 结论 MCI - 15 4可显著改善失血性休克兔和大鼠的心肌功能 ,减轻心肌细胞的损伤程度 ,对失血性休克心肌具有显著的保护作用。

Objective To evaluate the effect of new calcium sensitizer MCI-154 on myocardial structure and function of animal with hemorrhagic shock to find out function of MCI-154 on treatment of hemorrhagic shock. Methods Rabbit and rat hemorrhagic shock models were created and divided into MCI-154 treatment group and normal saline (NS) control group. The indexes of cardiac muscular blood flow dynamics in hemorrhagic shock rabbits, CK-MB and LDH of plasma level and changes of myocardial structure of rats with hemorrhagic shock were determined. Results After treatment with MCI-154, LVSP, +dp/dtmax, Lo and Vpm were increased significantly, LVEDP reduced markedly compared with the control group. The activity of CK-MB and LDH was weaker than that of the control group. The damage of myocardial cell structure was lighter than that of the control group. Conclusions MCI-154 can improve cardiac function, lighten cellular damage and protect the myocardium during hemorrhagic shock in rats and rabbits.