苏罗同预防化疗引起的恶心呕吐的临床效果

Clinical Efficacy of Serotone in Prevention of Emesis Induced by Anticancer Drugs

目的 观察苏罗同预防含顺铂或阿霉素方案化疗引起的恶心呕吐的临床疗效和不良反应。方法 对 3 0例患者采用随机自身对照研究的方法 ,分别在第 1周期化疗前用苏罗同、第 2周期用康泉预防呕吐 ,或第 1周期化疗前用康泉、第 2周期用苏罗同预防呕吐。结果 苏罗同和康泉第 1天预防呕吐的有效率均为 96.7%,患者第 1天平均呕吐次数分别为 1.3次和 1次 (P <0 .0 5 )。结论 苏罗同是预防细胞毒药物引起呕吐的有效药物 ,其不良反应可耐受。

Objective To evaluate the clinical efficacy and adverse effects of Serotone in prevention of nausea and vomiting induced by cisplatin and/or adriamycin containing regimens.Methods By a cross over randomized study,30 patients were observed.Seroton was used in the first cycle and kytril in the second cycle,or kytril in the first and seroton in the second,before infusion cisplatin and/or adriamycin.Results The response rates both were 96.7% for emesis prevention at the first day,and the mean value of emesis was 1.3 times in serotone and 1.0 time in kytril( P >0.05).Conclusion Serotone is an effective drug in prevention of emesis induced by cytotoxic drugs,while the advers effects are well tolerable by majority of patients.