HBV感染产前孕妇血清常量／微量元素检测及其临床意义

Detection of serum content of constant/trace element in HBV infected prenatal pregnant women and its clinical significance

目的探讨乙型肝炎病毒（HBV）感染产前孕妇血清钙、镁、锌、铁、铜含量与正常孕妇含量的差异，为HBV感染孕妇的婴儿提供喂养指导的依据。方法选择乙型肝炎表面抗原（HBsAg）阳性产前孕妇26例为HBV孕妇感染组，另一组为HBsAg阴性正常产前孕妇26例为正常对照组，用原子吸收光谱分析仪检测两组产前孕妇血清微量元素含量，比较两组差异性。结果正常对照组血清钙（2．69±0．75）、铜（29．27±12．35）高于产前孕妇HBV感染组（钙：2．24±0．24。铜21．79±10．42）．两组间有显著性差异，P值分别为0．02，0．02，血清镁、锌、铁含量两组间结果无显著性差异；血清钙、铜含量超出正常值上限人数的比率，正常对照组较HBV感染组明显偏高，两组间有显著性差异，P值分别为0．01，0．03；HBV感染同一组别中，乙型肝炎病毒e抗原（HBeAg）阳性与HBeg阴性两模式组间5种元素血清含量经统计学分析均无显著性差异，但HBeAg阴性组血清锌较阳性组有升高趋势。结论HBV感染产前孕妇较血清钙、镁、锌、铁、铜含量较正常产前孕妇低，尤以钙、铜为甚；HBeAg阴性组较HBeAg阳性组血清锌含量有增高趋势，有待进一步研究。

Objective To explore the difference in the prenatal serum content of calcium, magnesium, zinc, iron and copper between pregnant women infected with hepatitis B virus （HBV） and normal pregnant women, so as to provide basis for feeding guidance for infants of HVB infection women. Methods Twenty-six prenatal pregnant women with positive hepatitis b surface antigen （HBsAg） were selected in infection group, and control group included 26 cases of normal pregnant women with negative HBsAg. Atomic absorption spectrum analyzer was used to detect the trace element contents of them and comparison between them was made. Results In normal control group the serum contents of calcium （2.69 ±0. 75） and copper （29.27 ± 12.35） were higher than those in infection group （2.24 ±0. 24, 21.79 ± 10.42, respectively）, and the differences between them were significant （both P = 0.02）. But there was no significant difference in the serum contents of magnesium, zinc and iron between two groups. The ratio of patients with serum contents of calcium and copper above normal value limit in normal control group was obviously higher than that of HBV infection group, and the difference was significant （P value was 0. 01 and 0.03, respectively）. The difference in contents of five trace elements between cases with positive HBeAg and those with negative HBeAg in infection group was not significant, but the content of zinc in cases with negative HBeAg had increasing trend. Conclusion Compared with normal pregnant women, pregnant women infected with HBV have lower serum contents of calcium, magnesium, zinc, iron and copper, and calcium and copper contents are especially low. Compared with cases with positive HBeAg, the zinc content in serum in cases with negative HBeAg tends to rise, which needs further study.