老年男性睾酮水平与代谢综合征的关系

Relationship between Serum Testosterone and Metabolic Syndrome in Elderly Men

目的：探讨老年男性血清睾酮水平与代谢综合征（MS）的关系。方法：收集133例60~89岁男性病例,分成MS组72例和NMS组61例,分别测定患者的血清睾酮、雌二醇、甘油三酯、高密度脂蛋白、空腹血糖、空腹胰岛素,并以稳态模式评估胰岛素抵抗指数（HOMA-IR）评价患者的胰岛素敏感性。比较两组的睾酮、雌二醇/睾酮,分析血清中睾酮与代谢综合征的相关性。结果：MS组睾酮水平显著降低,而雌二醇/睾酮明显增高,比较差异具有统计学意义（P〈0.01）,随着MS组分增多,睾酮水平下降明显。在MS组中睾酮水平与年龄、腰围、体重指数、TG、HOMA-IR成负相关,与HDL-C正相关。结论：老年男性患者血清中低睾酮水平可增加MS的患病风险。

Objective： To investigate the relationship between serum testosterone and metabolic syndrome（MS） in elderly men. Method： 133 elderly men aged 60-89 years were divided into two groups： MS （72 cases） and NMS （61 cases） groups. Serum testosterone, estradiol, triglycerides, high-density lipoprotein cholesterol（HDL-C）, fasting blood glucose, fasting insulin were measured, and insulin sensitivity was evaluated by homeostasis model assessment of insulin resistance （HOMA-IR）. Serum testosterone and estradiol/testosterone between the two groups were compared, the correlation between serum testosterone and metabolic syndrome were analyzed. Result： Compared between the two groups, serum testosterone level was significantly lower in MS group than that in NMS group, and estradiol/testosterone obviously increased, the difference was statistically significant（P0.01）. Serum testosterone level decreased significantly with MS components increased. Correlation analyses showed that testosterone level was negatively associated with age, waist circumference, body mass index, TG and HOMA-IR in MS group, while it was positively associated with HDL-C. Conclusion： Low serum testosterone level appears to increase the risk for the developments of MS in elderly men.